This paper presents a multipoint optimization of the LS89 cascade. The objective of the optimization consists in minimizing the entropy losses generated inside the cascade over a predefined operating range. Two aerodynamic constraints are imposed in order to conserve the same performance as the original cascade. The first constraint is established on the outlet flow angle in order to achieve at least the same flow turning as the LS89. The second constraint limits the mass-flow passing through the cascade. The optimization is performed using a hybrid algorithm which combines a classical evolutionary algorithm with a gradient-based method. The hybridization between both methods is based on the Lamarckian approach which consists in incorporating the gradient method inside the loop of the evolutionary algorithm. In this methodology, the evolutionary method allows to globally explore the design space while the gradient-based method locally improves certain designs located in promising regions of the search space. First, the better performance of the hybrid method compared to the performance of an evolutionary algorithm is demonstrated on benchmark problems. Then, the methodology is applied on the LS89 application. The optimization allows to find a new profile which reduces the entropy losses over the entire operating range by at least 9.5 %. Finally, the comparison of the flows computed in the baseline and in the optimized cascades demonstrates that the reduction of the losses is due to a decrease of the entropy generated downstream the trailing edges and within the passages between the optimized blades.