The imperative improvement in the efficiency of turbofan engines is commonly facilitated by increasing the turbine inlet temperature (TIT). This development has reached a point where also components downstream of the high-pressure turbine (HPT) have to be adequately cooled. Such a component is the turbine center frame (TCF), known for a complex aerodynamic flow highly influenced by purge-mainstream interactions. The purge air, being injected through the wheelspace cavities of the upstream high-pressure turbine, bears a significant cooling potential for the TCF. Despite this, fundamental knowledge of the influencing parameters on heat transfer and film cooling in the TCF is still missing. This paper examines the influence of purge-to-mainstream blowing ratio, density ratio (DR), and purge swirl angle on heat transfer and film cooling in the TCF. The experiments are conducted in a sector-cascade test rig specifically designed for such heat transfer studies using infrared thermography and tailor-made flexible heating foils with constant heat flux. Three purge-to-mainstream blowing ratios and an additional no purge case are investigated. The purge flow is injected without swirl and also with engine-similar swirl angles. The purge swirl and blowing ratio significantly impact the magnitude and the spread of film cooling in the TCF. Increasing blowing ratios lead to an intensification of heat transfer. By cooling the purge flow, a moderate variation in purge-to-mainstream density ratio is investigated, and the influence is found to be negligible.