Internal flooding due to pipe breaks can interfere with a plant's ability to safely shut down or maintain the decay heat removal. Flooding simulation tools require information on location of pipe breaks and the degree of damage at each location as input for assessing the flooding risk. This can be especially challenging as the number of potential leakage locations are quite large and the state-of-the-art simulation tools cannot determine the degree of damage at a location. This paper presents a novel simulation-based framework that can be used to determine seismically induced flooding scenarios including the potential locations of leakage and the degree of leakage at each location. The proposed framework builds upon a few recent experimental and simulation-based studies on piping fragilities. This research identifies that a direct use of piping fragility information by flooding simulation tools is not appropriate. This paper presents a new approach that creates mutually exclusive and collectively exhaustive events to characterize the complete sample space at each location and employs the total probability theorem to characterize the probabilities for each event in this space. This paper also identifies the importance of including the temporal effects in the piping fragilities in order to allow a more realistic simulation of internal flooding scenarios.