1-5 of 5
Keywords: computational fluid dynamics
Close
Sort by
Journal Articles
Publisher: ASME
Article Type: Research-Article
J. Nanotechnol. Eng. Med. August 2013, 4(3): 031006.
Paper No: NANO-13-1085
Published Online: February 26, 2014
.... magnetic drug targeting stenosed blood vessel magnetic microsphere computational fluid dynamics pulsatile flow MDT is one of the major drug delivery methods that are used for treatment in different parts of our circulatory system. Among these different drug delivery methods, the magnetic...
Journal Articles
Publisher: ASME
Article Type: Research-Article
J. Nanotechnol. Eng. Med. February 2013, 4(1): 011001.
Paper No: NANO-12-1132
Published Online: July 11, 2013
... This review discusses current progress and future challenges in the numerical modeling of targeted drug delivery using functionalized nanocarriers (NC). Antibody coated nanocarriers of various size and shapes, also called functionalized nanocarriers, are designed to be injected in the vasculature, whereby they undergo translational and rotational motion governed by hydrodynamic interaction with blood particulates as well as adhesive interactions mediated by the surface antibody binding to target antigens/receptors on cell surfaces. We review current multiscale modeling approaches rooted in computational fluid dynamics and nonequilibrium statistical mechanics to accurately resolve fluid, thermal, as well as adhesive interactions governing nanocarrier motion and their binding to endothelial cells lining the vasculature. We also outline current challenges and unresolved issues surrounding the modeling methods. Experimental approaches in pharmacology and bioengineering are discussed briefly from the perspective of model validation....
Journal Articles
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. May 2011, 2(2): 021006.
Published Online: May 16, 2011
... achieving particles separation through the hydrodynamic method without the help from additional flow or force fields. High fidelity computational fluid dynamics with particle trajectory approach was employed for simulations. Particle separation of different sizes in the range 2 – 10 μ m size was achieved...
Journal Articles
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. November 2010, 1(4): 041005.
Published Online: October 21, 2010
... stenosed blood vessel magnetic microsphere hemodynamic flow computational fluid dynamics Drug targeting is a principle by which the distribution of therapeutic agents (drugs) is maneuvered in vivo such that a larger fraction of the dosed medicine reaches the affected regions in the body...
Journal Articles
Publisher: ASME
Article Type: Research Papers
J. Nanotechnol. Eng. Med. May 2010, 1(2): 021005.
Published Online: May 5, 2010
... applications of nanomechanical forces with the promise of inducing regeneration or changing the trajectory of degenerative cellular processes. biomechanics bioMEMS cellular biophysics computational fluid dynamics diseases microfluidics patient monitoring 29 01 2010 12 02 2010 05...