Generating liquid droplets is ideal for many applications including respiratory drug delivery because the droplets have uniform properties and can be easily controlled, sampled, and analyzed. In this study, a micropump-based droplet generator is proposed to produce the liquid droplets of micron to nano size. Numerical simulations were carried out to evaluate the ability of the proposed droplet generator device to produce liquid droplets. The velocity and diameter of the droplets generated by the droplet generator device were calculated, and the performance of the device’s flow rate and power consumption was evaluated. The effects of actuation frequency, actuation modes, and nozzle geometry on the performance of the device were investigated. Results showed that the proposed device can produce micron-/nano-sized liquid droplets with low power and the advantages of the proposed droplet generator device over traditional devices were discussed.

References

1.
Boer
,
A. H.
,
Wissink
,
J.
,
Hagedoorn
,
P.
,
Heskamp
,
I.
,
Kruijf
,
W.
,
Bünder
,
R.
,
Zanen
,
P.
,
Munnik
,
P.
,
Rijn
,
C. V.
, and
Frijlink
,
H. W.
, 2008, “
In Vitro Performance Testing of the Novel Medspray® Wet Aerosol Inhaler Based on the Principle of Rayleigh Break-Up
,”
Pharm. Res.
,
25
(
5
), pp.
1186
1192
.
2.
David
,
F.
, and
Driscoll
,
J.
, 2006, “
Lipid Injectable Emulsions: Pharmacopeial and Safety Issues
,”
Pharm. Res.
,
23
(
9
), pp.
1959
1969
.
3.
Berkland
,
C.
,
Pollauf
,
E.
,
Varde
,
N.
,
Pack
,
D. W.
, and
Kim
,
K.
, 2007, “
Monodisperse Liquid-Filled Biodegradable Microcapsules
,”
Pharm. Res.
,
24
(
5
), pp.
1007
1013
.
4.
German-Fattal
,
M.
, and
Mösges
,
R.
, 2004, “
How to Improve Current Therapeutic Standards in Upper Respiratory Infections: Value of Fusafungine
,”
Curr. Med. Res. Opin.
,
20
(
11
), pp.
1769
1776
.
5.
Louey
,
M. D.
,
Oort
M. V.
, and
Hickey
H. J.
, 2004, “
Aerosol Dispersion of Respirable Particles in Narrow Size Distributions Using Drug-Alone and Lactose-Blend Formulations
,”
Pharm. Res.
,
21
(
7
), pp.
1207
1213
.
6.
Asgharian
,
B.
,
Fang
,
C. P.
, and
Cohen
,
B. S.
, 1992, “
Generation of Submicron Mass/Volume-Monodisperse Aerosols With a Nebulizer-Impactor-Electrostatic Classifier System
,”
Aerosol Sci. Technol.
,
16
(
2
), pp.
96
104
.
7.
Ilie
,
M.
,
Matida
,
E. A.
, and
Finlay
,
W. H.
, 2008, “
Asymmetrical Aerosol Deposition in an Idealized Mouth With a DPI Mouthpiece Inlet
,”
Aerosol Sci. Technol.
,
42
(
1
), pp.
10
17
.
8.
Yeo
,
L. Y.
, and
Friend
,
J.
, 2009, “
Ultrafast Microfluidics Using Surface Acoustic Waves
,”
Biomicrofluidics
,
3
, p.
012002
.
9.
Peters
,
T. M.
,
Chein
,
H.
,
Lundgren
,
D. A.
, and
Berntsen
,
J.
, 1994, “
Submicrometer Aerosol Generator Development for the U.S. Environmental Protection Agency’s Human Exposure Laboratory
,”
Aerosol Sci. Technol.
,
20
(
1
), pp.
51
61
.
10.
Kobayashi
,
I.
,
Takano
,
T.
,
Maeda
,
R.
, and
Wada
,
Y.
, 2008, “
Straight-Through Microchannel Devices for Generating Monodisperse Emulsion Droplets Several Microns in Size
,”
Microfluid Nanofluid.
,
4
, pp.
167
177
.
11.
Dhand
,
R.
, 2002, “
Nebulizers That Use a Vibrating Mesh or Plate With Multiple Apertures to Generate Aerosol
,”
Respir. Care
,
47
(
12
), pp.
1406
1416
.
12.
Skaria
,
S.
,
Smaldone
,
G. C.
, and
Omron
N. E.
, 2010, “
Comparison between Vibrating Mesh and Jet Nebulizer
,”
J. Aerosol Med. Pulm. Drug Deliv.
,
23
(
3
), pp.
173
180
.
13.
Yeo
,
L. Y.
,
Friend
,
J.
,
McIntosh
,
M.
,
Meeusen
,
E.
, and
Morton
,
D.
, 2010, “
Ultrasonic Nebulization Platforms for Pulmonary Drug Delivery
,”
Expert Opin. Drug Deliv.
,
7
(
6
), pp.
663
679
.
14.
Denyer
,
J.
,
Dyche
,
T.
, and
Nikander
,
K.
, 1997, “
A Novel Liquid Drug Aerosol Delivery System
,”
Thorax
,
52
(
6
), p.
208
.
15.
Waldrep
,
J. C.
, and
Dhand
,
R.
, 2008, “
Advanced Nebulizer Designs Employing Vibrating Mesh/Aperture Plate Technologies for Aerosol Generation
,”
Curr. Drug Deliv.
,
5
, p.
114
.
16.
Kelly
,
J. T.
,
Asgharian
,
B.
,
Kimbell
,
J. S.
, and
Wong
,
B.
, 2004, “
Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part II: Ultrafine Particles
,”
Aerosol Sci. Technol.
,
38
(
11
), pp.
1072
1079
.
17.
Golshahi
,
L.
,
Finlay
,
W. H.
,
Olfert
,
J. S.
,
Thompson
,
R. B.
, and
Noga
,
M. L.
, 2010, “
Deposition of Inhaled Ultrafine Aerosols in Replicas of Nasal Airways of Infants
,”
Aerosol Sci. Technol.
,
44
(
9
), pp.
741
752
.
18.
Martin
,
A. R.
, and
Finlay
,
W. H.
, 2005, “
The Effect of Humidity on the Size of Particles Delivered from Metered-Dose Inhalers
,”
Aerosol Sci. Technol.
,
39
(
4
), pp.
283
289
.
19.
Hrvacic
,
B.
,
Bosnjak
,
B.
,
Tudja
,
M.
,
Mesic
,
M.
, and
Mercep
,
M.
, 2006, “
Applicability of an Ultrasonic Nebulization System for the Airways Delivery of Beclomethasone Dipropionate in a Murine Model of Asthma
,”
Pharm. Res.
,
23
(
8
), pp.
1765
1775
.
20.
Kundoor
,
V.
, and
Dalby
,
R. N.
, 2010, “
Assessment of Nasal Spray Deposition Pattern in a Silicone Human Nose Model Using a Color-Based Method
,”
Pharm. Res.
,
27
, pp.
1
10
.
21.
Kwok
,
K. K.
,
Groves
,
M. J.
, and
Burgess
,
D. J.
, 1991, “
Production of 5-15 Microns Diameter Alginate-Polylysine Microcapsules by an Air-atomization Technique
,”
Pharm. Res.
,
8
(
3
), pp.
341
344
.
22.
Gemci
,
T.
,
Corcoran
,
T. E.
, and
Chigier
,
N.
, 2002, “
A Numerical and Experimental Study of Spray Dynamics in a Simple Throat Model
,”
Aerosol Sci. Technol.
,
36
(
1
), pp.
18
38
.
23.
Ben-Jebria
,
A.
,
Eskew
,
M. L.
, and
Edwards
,
D.
, 2000, “
Inhalation System for Pulmonary Aerosol Drug Delivery in Rodents Using Large Porous Particles
,”
Aerosol Sci. Technol.
,
32
(
5
), pp.
421
433
.
24.
Suman
,
J. D.
,
Laube
,
B. L.
, and
Dalby
,
R.
, 1999, “
Comparison of Nasal Deposition and Clearance of Aerosol Generated by a Nebulizer and an Aqueous Spray Pump
,”
Pharm. Res.
,
16
(
1
), pp.
1648
1652
.
25.
Byron
,
P. R.
, 1993, “
Physicochemical Effects on Lung Disposition of Pharmaceutical Aerosols
,”
Aerosol Sci. Technol.
,
18
(
3
), pp.
223
229
.
26.
Byron
,
P. R.
, and
Patton
,
J. S.
, 1994, “
Drug Delivery via the Respiratory Tract
,”
J. Aerosol Med.
,
7
(
1
), pp.
49
75
.
27.
Byron
,
P. R.
,
Roberts
,
N. S.
, and
Clark
,
A. R.
, 1986, “
An Isolated Perfused Rat Lung Preparation for the Study of Aerosolized Drug Deposition and Absorption
,”
J. Pharm. Sci.
,
75
(
2
), pp.
168
171
.
28.
Ehtezazi
,
K. W.
,
Southern
,
D.
,
Allanson
,
I. J.
, and
O’Callaghan
,
C.
, 2005, “
Suitability of the Upper Airway Models Obtained from MRI Studies in Simulating Drug Lung Deposition from Inhalers
,”
Pharm. Res.
,
22
(
1
), pp.
166
170
.
29.
Keller
,
M.
,
Schuschnig
,
U.
, and
Möller
,
W.
, 2010, “
Pulsating Aerosols for Sinus Drug Delivery: New Treatment Options & Perspectives in Chronic Rhinosinusitis
,” ONdrugDelivery, pp.
20
24
, www.ondrugdelivery.comwww.ondrugdelivery.com.
30.
Dayal
,
P.
,
Shaik
,
M. S.
, and
Singh
,
M.
, 2004, “
Evaluation of Different Parameters That Affect Droplet-Size Distribution from Nasal Sprays Using the Malvern Spraytec1
,”
J. Pharm. Sci.
,
93
(
7
), pp.
1725
1742
.
31.
Möller
,
W.
,
Schuschnig
,
U.
,
Saba
,
G. K.
,
Meyer
,
G.
,
Junge-Hülsing
,
B.
,
Keller
,
M.
, and
Häussinger
,
K.
, 2010, “
Pulsating Aerosols for Drug Delivery to the Sinuses in Healthy Volunteers, Otolaryngol
,”
Head Neck Surg.
,
142
, pp.
382
388
.
32.
Suman
,
J. D.
,
Laube
,
B. L.
,
Lin
,
T.
,
Brouet
,
G.
, and
Dalby
,
R.
, 2002, “
Validity of In Vitro Tests on Aqueous Spray Pumps as Surrogates for Nasal Deposition
,”
Pharm. Res.
,
19
(
1
), pp.
1
6
.
33.
Alvarez
,
M.
,
Yeo
,
L. Y.
, and
Friend
,
J. R.
, 2009, “
Rapid Production of Protein Loaded Biodegradable Microparticles Using Surface Acoustic Waves
,”
Biomicrofluidics
,
3
, p.
014102
.
34.
Niven
,
R. W.
,
Ip
,
A. Y.
,
Mittelman
,
S.
,
Prestrelski
,
S. J.
, and
Arakawa
,
T.
, 1995, “
Some Factors Associated With the Ultrasonic Nebulization of Proteins
,”
Pharm. Res.
,
12
(
1
), pp.
53
59
.
35.
Su
,
G.
,
Longest
,
P. W.
, and
Pidaparti
,
R. M.
, 2010, “
A Novel Micropump Droplet Generator for Aerosol Drug Delivery: Design Simulations
,”
Biomicrofluidics
,
4
, p.
044108
.
36.
Su
,
G.
, and
Pidaparti
,
R. M.
, 2010, “
Drug Particle Delivery Investigation through a Valveless Micropump
,”
J. Microelectromech. Syst.
,
19
(
6
), pp.
1390
1399
.
37.
Xia
,
Y.
,
Whitesides
,
G. M.
, and
Angew
,
C.
, 1998, “
Soft Lithography
,”
Angew. Chem. Int. Ed. Engl.
,
37
(
5
), pp.
550
575
.
38.
Brackbill
,
J. U.
,
Kothe
,
D. B.
, and
Zemach
,
C. A.
, 1992, “
Continuum Method for Modelling Surface Tension
,”
J. Comput. Phys.
,
100
, pp.
335
354
.
39.
Kundu
,
P. K.
, and
Cohen
,
I. M.
, 2008,
Fluid Mechanics
,
Academic
,
New York
.
40.
McCallion
,
O. N. M.
,
Taylor
,
K. M. G.
,
Thomas
,
M.
, and
Taylor
,
A. J.
, 1995, “
Nebulization of Fluids of Different Physicochemical Properties With Air Jet and Ultrasonic Nebulizers
,”
Pharm. Res.
,
12
(
11
), pp.
1682
1688
.
41.
Niven
,
R. W.
, and
Schreier
,
H.
, 1990, “
Nebulization of Liposomes: Effects of Lipid Composition
,”
Pharm. Res.
,
7
(
11
), pp.
1127
1133
.
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