An outbreak of severe acute respiratory syndrome (SARS) novel coronavirus-2 (SARS-nCoV-2) caused unprecedented ongoing health and socioeconomic crises. So far, millions have got infected, living with life-threatening challenges. The corporate world is striving to survive. The scientific community explores various strategies to invent vaccines and/or therapeutic options to control this viral pandemic. This SARS-nCoV-2 is highly contagious and can be exponentially transmitted from human to human. Most of the patients have similar pneumonia symptoms, and at a later stage, it causes lung damage, breathing difficulties, and reduced gas exchange. More specifically, this infection exacerbates the problem in the case of secondary illness or disease. There is a striving need for a novel strategy to control the virus spread and treat related pathogens with all these challenges. Researchers have suggested some natural compounds (curcumin, quercetin, cinnamaldehyde, and lactoferrin), nutraceuticals, probiotics, and vitamin therapy for immune-boosting because they have high anti-inflammatory effects. Here, in this review, we compiled the updated information on the current status, clinical symptoms, pathogenesis, possible new green targets (herbal medicine), and challenges associated with developing potential vaccines.