Superparamagnetic iron oxide nanoparticles are of interest for use as magnetic resonance imaging contrast agents and in thermal therapies. Silica nanoparticle coatings can increase the thermal stability of particles and provide a biologically inert surface for the attachment of functionalizing ligands. In this study, silica-coated magnetic iron oxide nanoparticles were produced by synthesizing core iron oxide nanoparticles in a thermal plasma followed by coating the particles with silica by photoinduced chemical vapor deposition (photo-CVD). Core particles were shown to be superparamagnetic with a maximum saturation magnetization of 29 emu/g. The photo-CVD process produced silica coatings with thicknesses up to 6 nm. Coatings were found to consist of conformal high-purity silica. The presence of the coating was found to decrease the saturation magnetization when evaluated on a total mass basis (iron oxide and silica).
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Synthesis of Silica-Coated Iron Oxide Nanoparticles for Magnetic Resonance Contrast Enhancement and Thermal Therapies
Steven Girshick
Steven Girshick
University of Minnesota
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Steven Calder
University of Minnesota
Adam Boies
University of Minnesota
Pingyan Lei
University of Minnesota
Steven Girshick
University of Minnesota
J. Med. Devices. Jun 2011, 5(2): 027534 (1 pages)
Published Online: June 14, 2011
Article history
Online:
June 14, 2011
Published:
June 14, 2011
Citation
Calder, S., Boies, A., Lei, P., and Girshick, S. (June 14, 2011). "Synthesis of Silica-Coated Iron Oxide Nanoparticles for Magnetic Resonance Contrast Enhancement and Thermal Therapies." ASME. J. Med. Devices. June 2011; 5(2): 027534. https://doi.org/10.1115/1.3591376
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