Retransfusion of a patient's own shed blood during cardiac surgery is attractive since it reduces the need for allogeneic transfusion, minimizes cost, and decreases transfusion related morbidity. Evidence suggests that lipid micro-emboli associated with the retransfusion of the shed blood are the predominant causes of the neurocognitive disorders. We have developed a novel acoustophoretic filtration system that can remove lipids from blood at clinically relevant flow rates. Unlike other acoustophoretic separation systems, this ultrasound technology works at the macroscale, and is therefore able to process larger flow rates than typical micro-electromechanical system (MEMS) scale acoustophoretic separation devices. In this work, we have first demonstrated the systematic design of the acoustic device and its optimization, followed by examining the feasibility of the device to filter lipids from the system. Then, we demonstrate the effects of the acoustic waves on the shed blood; examining hemolysis using both haptoglobin formation and lactate dehydrogenase release, as well as the potential of platelet aggregation or inflammatory cascade activation. Finally, in a porcine surgical model, we determined the potential viability of acoustic trapping as a blood filtration technology, as the animal responded to redelivered blood by increasing both systemic and mean arterial blood pressure.
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March 2018
Research-Article
A Novel Macroscale Acoustic Device for Blood Filtration
Brian Dutra,
Brian Dutra
College of Engineering,
Western New England University,
Springfield, MA 01119;
Western New England University,
Springfield, MA 01119;
Flo Design Sonics Inc.,
Wilbraham, MA 01095
Wilbraham, MA 01095
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Maria Carmen Mora,
Maria Carmen Mora
Department of Surgery,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
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Tyler I. Gerhardson,
Tyler I. Gerhardson
College of Engineering,
Western New England University,
Springfield, MA 01119
Western New England University,
Springfield, MA 01119
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Brianna Sporbert,
Brianna Sporbert
College of Engineering,
Western New England University,
Springfield, MA 01119
Western New England University,
Springfield, MA 01119
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Alexandre Dufresne,
Alexandre Dufresne
Baystate Research Facility,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
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Katharine R. Bittner,
Katharine R. Bittner
Department of Surgery,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
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Carolanne Lovewell,
Carolanne Lovewell
Baystate Research Facility,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
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Michael J. Rust,
Michael J. Rust
College of Engineering,
Western New England University,
Springfield, MA 01119
Western New England University,
Springfield, MA 01119
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Michael V. Tirabassi,
Michael V. Tirabassi
Department of Surgery,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
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Louis Masi,
Louis Masi
Flo Design Sonics Inc.,
Wilbraham, MA 01095
Wilbraham, MA 01095
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Bart Lipkens,
Bart Lipkens
College of Engineering,
Western New England University,
Springfield, MA 01119;
Western New England University,
Springfield, MA 01119;
Flo Design Sonics Inc.,
Wilbraham, MA 01095
Wilbraham, MA 01095
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Daniel R. Kennedy
Daniel R. Kennedy
College of Pharmacy,
Western New England University,
Springfield, MA 01119
e-mail: dkennedy@wne.edu
Western New England University,
1215 Wilbraham Road
,Springfield, MA 01119
e-mail: dkennedy@wne.edu
Search for other works by this author on:
Brian Dutra
College of Engineering,
Western New England University,
Springfield, MA 01119;
Western New England University,
Springfield, MA 01119;
Flo Design Sonics Inc.,
Wilbraham, MA 01095
Wilbraham, MA 01095
Maria Carmen Mora
Department of Surgery,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
Tyler I. Gerhardson
College of Engineering,
Western New England University,
Springfield, MA 01119
Western New England University,
Springfield, MA 01119
Brianna Sporbert
College of Engineering,
Western New England University,
Springfield, MA 01119
Western New England University,
Springfield, MA 01119
Alexandre Dufresne
Baystate Research Facility,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
Katharine R. Bittner
Department of Surgery,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
Carolanne Lovewell
Baystate Research Facility,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
Michael J. Rust
College of Engineering,
Western New England University,
Springfield, MA 01119
Western New England University,
Springfield, MA 01119
Michael V. Tirabassi
Department of Surgery,
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
University of Massachusetts Medical
School-Baystate,
Springfield, MA 01109
Louis Masi
Flo Design Sonics Inc.,
Wilbraham, MA 01095
Wilbraham, MA 01095
Bart Lipkens
College of Engineering,
Western New England University,
Springfield, MA 01119;
Western New England University,
Springfield, MA 01119;
Flo Design Sonics Inc.,
Wilbraham, MA 01095
Wilbraham, MA 01095
Daniel R. Kennedy
College of Pharmacy,
Western New England University,
Springfield, MA 01119
e-mail: dkennedy@wne.edu
Western New England University,
1215 Wilbraham Road
,Springfield, MA 01119
e-mail: dkennedy@wne.edu
1Corresponding author.
Manuscript received July 21, 2017; final manuscript received November 7, 2017; published online January 19, 2018. Assoc. Editor: Matthew R. Myers.
J. Med. Devices. Mar 2018, 12(1): 011008 (7 pages)
Published Online: January 19, 2018
Article history
Received:
July 21, 2017
Revised:
November 7, 2017
Citation
Dutra, B., Carmen Mora, M., Gerhardson, T. I., Sporbert, B., Dufresne, A., Bittner, K. R., Lovewell, C., Rust, M. J., Tirabassi, M. V., Masi, L., Lipkens, B., and Kennedy, D. R. (January 19, 2018). "A Novel Macroscale Acoustic Device for Blood Filtration." ASME. J. Med. Devices. March 2018; 12(1): 011008. https://doi.org/10.1115/1.4038498
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