The breakup of liquid films in high-speed flows is found in many applications. These include prefilming air blast atomization found in fuel injectors and shedding of droplet off of airfoils. In this work, a test rig has been developed and applied to study the breakup of water films from the trailing edge of an NACA 0012 airfoil placed in a high-speed air flow. The results provided reflect a new detailed dataset focused on air velocities above 75 m/s. Computational fluid dynamic (CFD) simulations were used to guide the development of the rig and the associated boundary and inlet conditions. In this work, air velocities up to 175 m/s were used with water films between 0.4 cm2/s and 3.6 cm2/s. The water film was introduced onto one surface through a series of 0.5 mm holes separated by 1 mm at a location 35 mm downstream of the leading edge of the vane. High speed video was used to document the sheet breakup behavior from the edge of the airfoil. Image analysis was used to identify the breakup length of ligaments formed. Laser diffraction was used 50 mm downstream of the trailing edge of the vane to determine the droplet size distribution and associated representative average diameters generated. A series of test conditions were run between 50 m/s and 175 m/s using multilevel factorial designed experiments. The results obtained were subjected to analysis of variance to generate correlations for breakup length and droplet representative diameters as a function of the conditions studied. The analysis was conducted on dimensionless versions of the variables studied to help connect the results to the physics of the situation. For example, rather than using air velocity to correlate the behavior, the Weber number (based on gas phase density and velocity) was used owing to its historical ability to describe liquid breakup processes. The results obtained are compared with other studies in the literature, and good agreement was found for the conditions at which a comparison could be made. It is observed that, for the conditions studied, liquid film thickness has little effect on the resulting droplet sizes—especially for the higher air velocity cases studied. The results also illustrate the sensitivity to choice of the characteristic length, which is generally consisted of trailing edge geometry or boundary layer thickness. In contrast, liquid film does influence the ligament breakup length, although the time to break up is less affected. Overall, the correlations developed provide engineering tools to help estimate ligament and drop size behavior for water films shed from airfoils in a high-speed flow.