Two methods are used to study the process of particle deposition in a turbulent pipe flow. The Monte Carlo method tracks 10,000 particles in the turbulent pipe flow to reproduce the deposition process of the particles. The deposition velocity of the particles is determined by calculating the proportion of particles passing through the test section. The simplified deposition model uses an equivalent Markov motion instead of the radial movement of the particle in the turbulent core. The probability that a particle leaves the turbulent core depends on the radial particle position and the probability density distribution of the random vortex. The probability that a particle penetrates the boundary layer can be solved by integrating the probability density distribution of radial particle velocity. The deposition velocity of particles can be obtained by calculating the probability of an individual particle leaving the turbulent core and penetrating the boundary layer. Five experimental data series from the literature are applied to examine the predictive abilities of the two methods. The results demonstrate that the Monte Carlo method can be properly used to track the particle deposition process in the diffusion–impaction and inertia-moderated regimes. The simplified model is suitable for high-inertia particles.