The model uncertainty of the steer-by-wire (SbW) system and the limitation of communication bandwidth will have a negative effect on its control performance. For this reason, this paper proposes an event-triggered high-order sliding mode control for uncertain SbW systems. First, to save communication and computing resources, an event-triggering mechanism that depends on the system state is proposed for the SbW system, such that both communication and computing resources can be saved. Second, an event-triggered adaptive higher-order sliding mode (ET-AHOSM) control is proposed for the closed-loop SbW system. The assumptions about the global Lipschitz of nonlinearity and the a priori bounds of the disturbance are no longer required in the control design. Much importantly, the control input continuity can be guaranteed even there is the event-triggering communication in the controller-to-actuator channel. Theoretical analysis shows that the global practical finite-time stability of the closed-loop SbW system can be obtained while avoiding Zeno behavior of the event-triggered control system. Finally, numerical simulation and experiments show that the designed control method can reduce more than 1/2 of the calculation and communication resources while ensuring satisfactory tracking accuracy.