...] Humphrey , J. D. , Schwartz , M. A. , Tellides , G. , and Milewicz , D. M. , 2015 , “ Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections ,” Circ. Res. , 116 ( 8 ), pp. 1448 – 1461 . 10.1161/CIRCRESAHA.114.304936 [20...

... and biomechanical forces influence disease growth. Wall shear stress (WSS) affects coronary artery atherosclerosis by inducing endothelial cell mechanotransduction and by controlling the near-wall transport processes involved in atherosclerosis. Each of these processes is controlled by WSS differently and therefore...

... mechanotransduction vasocontraction smooth muscle function Arterial vasoactivity is an important consideration when investigating mechanisms that prevent or drive cardiovascular disease. Maintenance of smooth muscle tone contributes to vascular homeostasis in many ways: it modulates systemic blood pressure...

... that, if answered, have the potential to dramatically improve current therapeutic strategies for the repair and regeneration of damaged myocardium via mechanotransductive signaling. extracellular matrix mechanotransduction cardiac fibroblasts A significant paradigm shift in the role...

... in Hepatic Stellate Cell Activation and Liver Fibrosis ,” J. Clin. Gastroenterol. , 39 ( 4 ), pp. S158 – S161 . 10.1097/01.mcg.0000155516.02468.0f [6] Schwartz , M. A. , and DeSimone , D. W. , 2008 , “ Cell Adhesion Receptors in Mechanotransduction ,” Curr. Opin. Cell Biol. , 20 ( 5...

... the physiological implications of tissue loading in all conditions, a review of mechanotransduction pathways in the cartilage, ligament and bone is also presented ranging from the tissue-level scale to cellular modifications. With this context, experimental studies are summarized as they relate to the most common...

... gratefully acknowledge the useful discussions with M. Rubin. Wang , N. , Butler , J. P. , and Ingber , D. E. , 1993 , “ Mechanotransduction Across the Cell Surface and Through the Cytoskeleton ,” Science 0036-8075 , 260 ( 5111 ), pp. 1124 – 1127 . 10.1126/science.7684161...

... and FGF-2 in 3D culture. In conclusion, gene expression is different between 2D and 3D osteoblast cultures under static conditions. Additionally, osteoblasts respond to shear stress differently in 2D and 3D cultures. Our results highlight the importance of 3D mechanotransduction studies for bone tissue...

... experimental loading scenarios. mechanical conditioning mechanotransduction volumetric growth There is a great unmet clinical need to develop small diameter tissue engineered blood vessels (TEBVs) with low thrombogenicity and immune response, suitable mechanical properties, and a capacity to adapt...

... regarding how ECM microstructure participates in the transmission of mechanical load information from a global (tissue or construct) level to a level local to the resident cells ultimately initiating relevant mechanotransduction pathways. In this study, the transmission of mechanical strains at various...

... engineering cone-and-plate viscometer bioreactor shear stress heart valve tissue engineering mechanotransduction Cardiovascular tissue is subjected to a complex combination of mechanical stimuli such as pressure, bending and tensile stretches, and flow. These forces potently regulate...

..., and a time constant of 1.32±0.65 s. To our knowledge, this is the first time that stress-controlled indentation testing has been applied at the single cell level. This methodology represents a new tool in understanding the mechanical nature of anchorage-dependent cells and mechanotransductional pathways...

... boundary-elements methods biological techniques physiological models boundary integral equations Cartilage Osteoarthritis Cell Mechanics Chondrocyte Mechanotransduction Articular cartilage serves as the resilient load-bearing surface at the ends of long bones in diarthroidal joints...

... April 2002 30 07 2002 cellular biophysics blood vessels haemodynamics pulsatile flow physiological models proteins molecular biophysics mechanoception Blood Flow Mechanotransduction Migration eNOS In the human circulatory system, blood flow in arteries is highly...

... Mechanotransduction Articular cartilage serves as the resilient load-bearing surface at the ends of long bones in diarthroidal joints. Cartilage contains a single population of cells, known as chondrocytes, which are responsible for the turnover and maintenance of the extracellular matrix. In addition...