...M. Kojic; J. P. Butler; I. Vlastelica; B. Stojanovic; V. Rankovic; A. Tsuda Low Reynolds number airflow in the pulmonary acinus and aerosol particle kinetics therein are significantly conditioned by the nature of the tidal motion of alveolar duct geometry. At least two components of the ductal...

... aerosol particles are influenced by convective airflow patterns. Therefore, understanding alveolar fluid flow and mixing is a necessary first step toward predicting aerosol transport and deposition in the human acinar region. In this study, flow patterns and particle transport have been measured using...

... are not well understood. Many physiological conditions are suspected to influence particle deposition including morphometry of the acinus, expansion and contraction of the alveolar walls, lung heterogeneities, and breathing patterns. Some studies suggest that the recirculation zones trap aerosol particles...

...Josué Sznitman; Thomas Heimsch; Johannes H. Wildhaber; Akira Tsuda; Thomas Rösgen The inhalation of micron-sized aerosols into the lung’s acinar region may be recognized as a possible health risk or a therapeutic tool. In an effort to develop a deeper understanding of the mechanisms responsible...

... the dispersion and transport of therapeutic aerosols in the respiratory tract. A variety of mechanisms may contribute to convective dispersion in the lung; simple axial streaming, augmented dispersion, and steady streaming are investigated in this effort. Flow visualization of a bolus during inhalation...

...Jinxiang Xi; P. Worth Longest The deposition of ultrafine aerosols in the respiratory tract presents a significant health risk due to the increased cellular-level response that these particles may invoke. However, the effects of geometric simplifications on local and regional nanoparticle...

...Frank E. Fresconi; Ajay K. Prasad An understanding of flow and dispersion in the human respiratory airways is necessary to assess the toxicological impact of inhaled particulate matter as well as to optimize the design of inhalable pharmaceutical aerosols and their delivery systems. Secondary flows...

.... 05 12 2005 30 06 2006 lung pneumodynamics physiological models differential equations aerosols This paper models aerosol dispersion in the human lung by using a series of mixing tanks. The development of the model makes use of the experimental data given in Scherer et al...

...G. M. Allen; B. P. Shortall; T. Gemci; T. E. Corcoran; N. A. Chigier In order to understand mechanisms of gas and aerosol transport in the human respiratory system airflow in the upper airways of a pediatric subject (male aged 5) was calculated using Computational Fluid Dynamic techniques...

...C. Kleinstreuer; Z. Zhang One important research area of broad interest is the development of highly efficient drug delivery systems for desired site deposition and uptake. For example, controlled drug aerosol release and targeting to specific regions of the lung is a novel way to combat lung...

... have important effects on aerosol deposition within the throat. There is no correspondence noted between regions of high axial turbulence intensity and deposition. Boivin , G. , Goyette , N. , Hardy , I. , Aoki , F. , Wagner , A. , and Trottier , S. , 2000 , “ Rapid...