Tumor blood-flow is inhomogeneous because of heterogeneity in tumor vasculature, vessel-wall leakiness, and compliance. Experimental studies have shown that normalization of tumor vasculature by antiangiogenic therapy can improve tumor microcirculation and enhance the delivery of therapeutic agents to tumors. To elucidate the quantitative relationship between the vessel-wall compliance and permeability and the blood-flow rate in the microvessels of the tumor tissue, the tumor tissue with the normalized vasculature, and the normal tissue, we developed a transport model to simultaneously predict the interstitial fluid pressure (IFP), interstitial fluid velocity (IFV) and the blood-flow rate in a counter-current microvessel loop, which occurs from anastomosis in tumor-induced angiogenesis during tumor growth. Our model predicts that although the vessel-wall leakiness greatly affects the IFP and IFV, it has a negligible effect on the intravascular driving force (pressure gradient) for both rigid and compliant vessels, and thus a negligible effect on the blood-flow rate if the vessel wall is rigid. In contrast, the wall compliance contributes moderately to the IFP and IFV, but significantly to the vessel radius and to the blood-flow rate. However, the combined effects of vessel leakiness and compliance can increase IFP, which leads to a partial collapse in the blood vessels and an increase in the flow resistance. Furthermore, our model predictions speculate a new approach for enhancing drug delivery to tumor by modulating the vessel-wall compliance in addition to reducing the vessel-wall leakiness and normalizing the vessel density.
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e-mail: pguo@ccny.cuny.edu
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April 2012
Research Papers
Effect of Wall Compliance and Permeability on Blood-Flow Rate in Counter-Current Microvessels Formed From Anastomosis During Tumor-Induced Angiogenesis
Peng Guo,
Peng Guo
Department of Biomedical Engineering,
e-mail: pguo@ccny.cuny.edu
The City College of the City University of New York
, 160 Convent Avenue, New York
, NY 10031
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Bingmei M. Fu
Bingmei M. Fu
Department of Biomedical Engineering,
The City College of the City University of New York
, 160 Convent Avenue, New York
, NY 10031
Search for other works by this author on:
Peng Guo
Department of Biomedical Engineering,
The City College of the City University of New York
, 160 Convent Avenue, New York
, NY 10031e-mail: pguo@ccny.cuny.edu
Bingmei M. Fu
Department of Biomedical Engineering,
The City College of the City University of New York
, 160 Convent Avenue, New York
, NY 10031J Biomech Eng. Apr 2012, 134(4): 041003 (11 pages)
Published Online: April 6, 2012
Article history
Received:
June 30, 2011
Revised:
February 22, 2012
Posted:
March 15, 2012
Published:
April 5, 2012
Online:
April 6, 2012
Citation
Guo, P., and Fu, B. M. (April 6, 2012). "Effect of Wall Compliance and Permeability on Blood-Flow Rate in Counter-Current Microvessels Formed From Anastomosis During Tumor-Induced Angiogenesis." ASME. J Biomech Eng. April 2012; 134(4): 041003. https://doi.org/10.1115/1.4006338
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