Indocyanine green (ICG) dye angiography has been used by ophthalmologists for routine examination of the choroidal vasculature in human eyes for more than . In this study, a new approach is developed to extract information from ICG dye angiograms about blood velocity distribution in the choriocapillaris and its feeding blood vessels. ICG dye fluorescence intensity rise and decay curves are constructed for each pixel location in each image of the choriocapillaris in an ICG angiogram. It is shown that at each instant of time the magnitude of the local instantaneous dye velocity in the choriocapillaris is proportional to both the slope of the ICG dye fluorescence intensity curve and the dye concentration. This approach leads to determination of the absolute value of blood velocity in the choriocapillaris, assuming an appropriate scaling, or conversion factor can be determined. It also enables comparison of velocities in different regions of the choriocapillaris, since the conversion factor is independent of the vessel location. The computer algorithm developed in this study can be used in clinical applications for diagnostic purposes and for assessment of the efficacy of laser therapy in human eyes.
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e-mail: zliang@umbc.edu
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April 2006
Technical Papers
Feasibility of Extracting Velocity Distribution in Choriocapillaris in Human Eyes from ICG Dye Angiograms
L. Zhu,
L. Zhu
Department of Mechanical Engineering,
e-mail: zliang@umbc.edu
University of Maryland
, Baltimore County, Baltimore, MD 21250
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Y. Zheng,
Y. Zheng
Department of Mechanical Engineering,
University of Maryland
, Baltimore County, Baltimore, MD 21250
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C. H. von Kerczek,
C. H. von Kerczek
Department of Mechanical Engineering,
University of Maryland
, Baltimore County, Baltimore, MD 21250
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L. D. T. Topoleski,
L. D. T. Topoleski
Department of Mechanical Engineering,
University of Maryland
, Baltimore County, Baltimore, MD 21250
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R. W. Flower
R. W. Flower
Department of Ophthalmology,
University of Maryland at Baltimore
, Baltimore, MD 21250 and New York University
, New York, NY
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L. Zhu
Department of Mechanical Engineering,
University of Maryland
, Baltimore County, Baltimore, MD 21250e-mail: zliang@umbc.edu
Y. Zheng
Department of Mechanical Engineering,
University of Maryland
, Baltimore County, Baltimore, MD 21250
C. H. von Kerczek
Department of Mechanical Engineering,
University of Maryland
, Baltimore County, Baltimore, MD 21250
L. D. T. Topoleski
Department of Mechanical Engineering,
University of Maryland
, Baltimore County, Baltimore, MD 21250
R. W. Flower
Department of Ophthalmology,
University of Maryland at Baltimore
, Baltimore, MD 21250 and New York University
, New York, NYJ Biomech Eng. Apr 2006, 128(2): 203-209 (7 pages)
Published Online: October 20, 2005
Article history
Received:
August 2, 2004
Revised:
October 20, 2005
Citation
Zhu, L., Zheng, Y., von Kerczek, C. H., Topoleski, L. D. T., and Flower, R. W. (October 20, 2005). "Feasibility of Extracting Velocity Distribution in Choriocapillaris in Human Eyes from ICG Dye Angiograms." ASME. J Biomech Eng. April 2006; 128(2): 203–209. https://doi.org/10.1115/1.2165692
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