Trauma is the leading cause of death in people aged 1–44 years old, with hemorrhagic shock accounting for nearly half of these deaths. These fatalities often occur early, within 24 hours, but many are deemed potentially preventable with appropriate resuscitation. 1–2 The term “appropriate resuscitation” is somewhat ambiguous and subjective because of the lack of a standardized resuscitation protocol. We attribute this deficiency to our rudimentary understanding of the mechanisms of hemorrhagic shock and resuscitation.

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