Deposition of inhaled particles in the lung is one of the key factors for assessing toxic effects of airborne pollutant particles on one hand and for evaluating efficacy of inhalant pharmaceutical aerosols on the other side. Due to the geometric complexity and time-dependency of respiratory tracks, the correct prediction of the particle transport and deposition in the lung airway has been studied with experimental and computational approaches. The human alveolar duct, which connects the alveoli to the bronchioles of the lung, is recently the subject of interest within mathematical modeling because of its implications to drug delivery and ingestion of pollutants. Series of computational approaches have been performed to model the entire lung using 1-dimensional and “trumpet” model analyses [1,2]. Although these models represent with reasonable approximation of the regional particle deposition characteristics, they do not account for the local intricacy of particle transport and deposition in the acinus region, consisting of the alveolar duct and alveoli.

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