In this paper, we for the first-time synthesized vertically aligned polyaniline (PANI) nanowire arrays on flat-end AFM tips via template-free solution methods. 4-Aminothiophenol was used for tailoring the nucleation size, chain propagation and orientation of the PANI nanowires. The microscopy characterization indicated that diameter was centered at a mean of 33.7 nm with a standard deviation of 6.5 nm, and length was centered at a mean of 50.3 nm with a standard deviation of 7.6 nm. PANI nanowire arrays are non-toxic, low-cost, and tunable, and thus PANI nanowire-grown tips could perfectly simulate different nanosurfaces. Via the force spectroscopy, we demonstrate the feasibility in quantifying the nanostructure-cell interactions at the single cell level in real time with high reliability and accuracy. This work will enable a new tool in precisely quantifying the interactions of single living cells and nanosurface, and thus opens a new door to understand how single living cells sense and respond to the specific nanostructures.
- Manufacturing Engineering Division
Template-Free Fabrication of Aligned Nanoarray for Quantifying the Nanosurface-Single Cells Interaction
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Wang, B, Wang, L, & Wang, S. "Template-Free Fabrication of Aligned Nanoarray for Quantifying the Nanosurface-Single Cells Interaction." Proceedings of the ASME 2018 13th International Manufacturing Science and Engineering Conference. Volume 1: Additive Manufacturing; Bio and Sustainable Manufacturing. College Station, Texas, USA. June 18–22, 2018. V001T05A014. ASME. https://doi.org/10.1115/MSEC2018-6345
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