Separation of biologically active molecules (BAMs) is a problem for the pharmaceutical and biotechnology industries. Current technologies addressing this problem require too many techniques, toxic additives, and time to filter the desired materials. As a result, a new technology is needed. The objective of this work is to contribute to the development of a device that can separate 0.5 nm to 500 nm sized BAMs. A diaphragm valve is proposed that can control a gap created by two parallel flat surfaces. Position control is achieved by means of a piezoelectric actuator and a capacitive sensor. Modularity was also part of design considerations to address issues of eventual biocompatibility breakdown. Preliminary experiments indicate that gap separation can be controlled to increments of 0.2 nm.
- Design Engineering Division and Computers and Information in Engineering Division
Programmable Separation for Biologically Active Molecules
- Views Icon Views
- Share Icon Share
- Search Site
Gutierrez, MR, & Youcef-Toumi, K. "Programmable Separation for Biologically Active Molecules." Proceedings of the ASME 2006 International Mechanical Engineering Congress and Exposition. Design Engineering and Computers and Information in Engineering, Parts A and B. Chicago, Illinois, USA. November 5–10, 2006. pp. 13-20. ASME. https://doi.org/10.1115/IMECE2006-14141
Download citation file: