The ultimate goal of this work is to develop an automated MEMS-based lab-on-a-chip microinjector. This paper outlines one phase of that work: testing the feasibility of a pumpless, polysilicon MEMS microneedle for use in the proposed MEMS-based lab-on-a-chip microinjector. The pumpless MEMS microneedle operates on the principle of attraction and repulsion of DNA using electrostatic charges. Prototype microneedles were fabricated using a multi-layer surface micromachining process. DNA stained with a fluorescent dye (4‘, 6-DIAMIDINO-2-PHENYLINDOLE DIHYDROCHLORIDE or DAPI) was visualized using fluorescent illumination as the DNA was attracted to and repelled from the tips of MEMS microneedles using a 1.5 V DC source. The pumpless MEMS microneedle represents an important and significant step in the development of a self-contained, automated, MEMS-based microinjection system.
- Design Engineering Division and Computers in Engineering Division
Testing of a Pumpless MEMS Microinjection Needle Employing Electrostatic Attraction and Repulsion of DNA
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Aten, QT, Jensen, BD, & Burnett, SH. "Testing of a Pumpless MEMS Microinjection Needle Employing Electrostatic Attraction and Repulsion of DNA." Proceedings of the ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Volume 4: 20th International Conference on Design Theory and Methodology; Second International Conference on Micro- and Nanosystems. Brooklyn, New York, USA. August 3–6, 2008. pp. 723-730. ASME. https://doi.org/10.1115/DETC2008-49548
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