The conceptual design of a perfusion reactor is the subject of this paper. The main objective of the reactor is the provision of nutrients to living cells grown in a porous medium fabricated of a given ceramic foam. In order to increase reactor throughput, the nutrients should be provided in a minimum time, without affecting the cell life. Various layouts of identical ceramic-foam pieces hosting the cells are proposed, the purpose being to select the variant with the highest likelihood of optimum performance, in the absence of a detailed mathematical model. A simple model is proposed, drawn from the discipline of hydraulic dynamical systems, which leads to a flow-complexity measure. The variant with the lowest complexity is then selected, for which a possible embodiment is proposed.
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ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
August 3–6, 2008
Brooklyn, New York, USA
Conference Sponsors:
- Design Engineering Division and Computers in Engineering Division
ISBN:
978-0-7918-4328-4
PROCEEDINGS PAPER
The Conceptual Design of a Perfusion Reactor Using a Complexity Measure
Andreas Bischof,
Andreas Bischof
Technical University Berlin, Berlin, Germany
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Jorge Angeles,
Jorge Angeles
McGill University, Montreal, QC, Canada
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Lucienne Blessing
Lucienne Blessing
Universite´ du Luxembourg, Luxembourg
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Andreas Bischof
Technical University Berlin, Berlin, Germany
Jorge Angeles
McGill University, Montreal, QC, Canada
Lucienne Blessing
Universite´ du Luxembourg, Luxembourg
Paper No:
DETC2008-49266, pp. 429-436; 8 pages
Published Online:
July 13, 2009
Citation
Bischof, A, Angeles, J, & Blessing, L. "The Conceptual Design of a Perfusion Reactor Using a Complexity Measure." Proceedings of the ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Volume 4: 20th International Conference on Design Theory and Methodology; Second International Conference on Micro- and Nanosystems. Brooklyn, New York, USA. August 3–6, 2008. pp. 429-436. ASME. https://doi.org/10.1115/DETC2008-49266
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