The conceptual design of a perfusion reactor is the subject of this paper. The main objective of the reactor is the provision of nutrients to living cells grown in a porous medium fabricated of a given ceramic foam. In order to increase reactor throughput, the nutrients should be provided in a minimum time, without affecting the cell life. Various layouts of identical ceramic-foam pieces hosting the cells are proposed, the purpose being to select the variant with the highest likelihood of optimum performance, in the absence of a detailed mathematical model. A simple model is proposed, drawn from the discipline of hydraulic dynamical systems, which leads to a flow-complexity measure. The variant with the lowest complexity is then selected, for which a possible embodiment is proposed.
- Design Engineering Division and Computers in Engineering Division
The Conceptual Design of a Perfusion Reactor Using a Complexity Measure
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Bischof, A, Angeles, J, & Blessing, L. "The Conceptual Design of a Perfusion Reactor Using a Complexity Measure." Proceedings of the ASME 2008 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Volume 4: 20th International Conference on Design Theory and Methodology; Second International Conference on Micro- and Nanosystems. Brooklyn, New York, USA. August 3–6, 2008. pp. 429-436. ASME. https://doi.org/10.1115/DETC2008-49266
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