Failure and fault avoidance techniques are becoming important methodologies due to economical and ecological risks of modern technologies. The basic methodologies and techniques developing safe systems are connected with reliability engineering technologies or fault detection and isolation (FDI) approaches. The contribution introduces into the ideas of the 1997 firstly published SRCE (Safety and Reliability Control Engineering)-concept. Core of the approach is the development of a history- and load-dependent failure rate, which allows the online-calculation of reliability characteristics, which can be monitored or controlled. The classical definitions of reliability engineering characteristics are unfit due to the fact that they are only ‘driven’ by the time, so effects of changing operating conditions etc. can not be considered directly. The proposed approach solves this problem by introducing a new definition of a failure rate by introducing load- and lifetime-dependent failure rate. This also includes the possibility to consider regenerating/recovering effects of technical systems or components. As an example the determination is illustrated and applied to the monitoring of an automotive tire.