This paper presents studies of an upper body assistive device designed to aid human load carriage. The two primary functions of the device are: (i) distributing the backpack load between the shoulders and the waist and (ii) reducing the dynamic load of a backpack on the human body during walking. These functions are targeted to relieve stress applied on the shoulders and the back, and also reduce the dynamic loads transferred to the lower limbs during walking. These functions are achieved by incorporating two modules—passive and active—within a custom fitted shirt integrated with motion/force sensors, actuators, and a real-time controller. The relevant modeling and controller design are presented for dynamic load compensation. Preliminary evaluation of the device was first performed on a single subject, followed by a pilot study with ten healthy subjects walking on a treadmill with a backpack. Results show that the device can effectively transfer the load from the shoulders to the waist and also reduce the dynamic loads induced by the backpack during walking. Reduction in peak and total normal ground reaction forces, leg muscle activations, and oxygen consumptions was observed with the device. This suggests that the device can potentially reduce the risk of musculoskeletal injuries and fatigue on the lower limbs associated with carrying heavy loads and provide some metabolic benefits.