Open chain and closed chain manipulators are designed for specific objectives. Closed chain five bar manipulator is possible to be configured as a substitute to an open chain two degree of freedom (DoF) manipulator. Positional accuracy is one of the factors for performance evaluation, characterizing suitability of a configuration over the other. Present paper attempts comparative analysis of positional inaccuracy of closed chain five bar manipulator and serial chain configuration. Both manipulators are modeled for positional deviations under identical specifications considering randomness due to joint clearances and backlash in drive. The maximum positional inaccuracy is expressed in terms of dimensionless number as error index (EI) to estimate the comparative behavior of the manipulators. Positional error under influence of backlash and clearances is quantified. Comparison of two configurations is presented and conditional superiority of a configuration over the other is commented using geometric approach.